The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.

doi:10.1016/j.atherosclerosis.2011.08.019

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The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.

Atherosclerosis - 1 Dec 2011

Prudente Sabrina, Morini Eleonora, Larmon Jay, Andreozzi Francesco, Di Pietro Natalia, Nigro Angela, Gervino Ernest V, Mannino Gaia Chiara, Bacci Simonetta, Hauser Thomas H, Bellacchio Emanuele, Formoso Gloria, Pellegrini Fabio, Proto Vittoria, Menzaghi Claudia, Frittitta Lucia, Pandolfi Assunta, Sesti Giorgio, Doria Alessandro, Trischitta Vincenzo

Abstract excerpt

OBJECTIVE: Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variability, is associated with coronary artery disease (CAD) and/or myocardial infarction (MI) in...

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PMID: 21907990
DOI: 10.1016/j.atherosclerosis.2011.08.019
PMCID: PMC3728428

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