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Article

The genetics of hemoglobin A2 regulation in sickle cell anemia.

American journal of hematology - 1 Nov 2014

Griffin Paula J, Sebastiani Paola, Edward Heather, Baldwin Clinton T, Gladwin Mark T, Gordeuk Victor R, Chui David H K, Steinberg Martin H

Abstract excerpt

Hemoglobin A2 , a tetramer of α- and δ-globin chains, comprises less than 3% of total hemoglobin in normal adults. In northern Europeans, single nucleotide polymorphisms (SNPs) in the HBS1L-MYB locus on chromosome 6q and the HBB cluster on chromosome 11p were associated with HbA2 levels. We examined the genetic basis of HbA2 variability in sickle cell anemia using genome-wide association studies. HbA2 levels were...

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Source

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Identifiers

PMID: 25042611
DOI: 10.1002/ajh.23811
PMCID: PMC4298130

Genes

HBB
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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