Article
Causal links of α-thalassemia indices and cardiometabolic traits and diabetes: MR study.
Life science alliance - 1 Dec 2023
Hsu Lung-An, Wu Semon, Teng Ming-Sheng, Ko Yu-Lin
Abstract excerpt
Our study aimed to investigate if genetic variants around 16p13.3's HBA1 locus, associated with erythrocyte indices and HbA1c levels, predict α-thalassemia-related erythrocyte indices, cardiometabolic traits, and diabetes risk in Taiwanese individuals. We analyzed Taiwan Biobank data, including whole-genome sequencing from 1,493 participants and genotyping arrays from 129,542 individuals. First, we performed...
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