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Article

Diabetes mellitus and APOL1 genotype increase the risk for chronic kidney disease progression in sickle cell disease.

Blood - 12 Jun 2025

Sun Ryan, Srivastava Anand, Zapater Joseph L, Njoku Franklin, Han Jin, Ivy Zalaya, Farooqui Marwah, Rizvi Insia, Layden Brian, Molokie Robert E, Gordeuk Victor R, Saraf Santosh L

Abstract excerpt

ABSTRACT: We observed diabetes mellitus (DM) in 9.3% of adults with sickle cell disease (SCD), and DM predicted a sevenfold greater risk of chronic kidney disease progression adjusting for high-risk APOL1. Our results emphasize the clinical significance of DM in SCD.

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Topics

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Share to Anemia, Sickle Cell
Share to Apolipoprotein L1
Share to Apolipoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus

Share to Disease Progression

Share to Lipoproteins, HDL

Share to Renal Insufficiency, Chronic

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40112283
DOI: 10.1182/blood.2024027839
PMCID: PMC12226738

Genes

APOL1
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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