Article
Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.
PLoS computational biology - 1 May 2015
Karr Jonathan R, Williams Alex H, Zucker Jeremy D, Raue Andreas, Steiert Bernhard, Timmer Jens, Kreutz Clemens, Wilkinson Simon, Allgood Brandon A, Bot Brian M, Hoff Bruce R, Kellen Michael R, Covert Markus W, Stolovitzky Gustavo A, Meyer Pablo
Abstract excerpt
Whole-cell models that explicitly represent all cellular components at the molecular level have the potential to predict phenotype from genotype. However, even for simple bacteria, whole-cell models will contain thousands of parameters, many of which are poorly characterized or unknown. New algorithms are needed to estimate these parameters and enable researchers to build increasingly comprehensive models. We...
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