Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A whole-cell computational model predicts phenotype from genotype.

Cell - 20 Jul 2012

Karr Jonathan R, Sanghvi Jayodita C, Macklin Derek N, Gutschow Miriam V, Jacobs Jared M, Bolival Benjamin, Assad-Garcia Nacyra, Glass John I, Covert Markus W

Abstract excerpt

Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. We report a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes all of its molecular components and their interactions. An integrative approach to modeling that combines diverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Computer Simulation

Share to DNA-Binding Proteins

Share to Models, Biological

Share to Molecular Sequence Annotation

Share to Mycoplasma genitalium

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 22817898
DOI: 10.1016/j.cell.2012.05.044
PMCID: PMC3413483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A whole-cell computational model predicts phenotype from genotype.PMID 22817898Read ↗

Accelerated discovery via a whole-cell model.Semantic proximity Read ↗

Inferring single-cell protein levels and cell cycle behavior in heterogeneous cell populationsSemantic proximity Read ↗

Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.Semantic proximity Read ↗

Uncovering modeling features of viral replication dynamics from high-throughput single-cell virology experimentsSemantic proximity Read ↗

Contributions of cell growth and biochemical reactions to nongenetic variability of cells.Semantic proximity Read ↗

Digitize your Biology! Modeling multicellular systems through interpretable cell behaviorSemantic proximity Read ↗

Simulating single-cell metabolism using a stochastic flux-balance analysis algorithmSemantic proximity Read ↗

Quantifying landscape-flux via single-cell transcriptomics uncovers the underlying mechanism of cell cycleSemantic proximity Read ↗

Mutation dynamics and fitness effects followed in single cells.Semantic proximity Read ↗

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlSemantic proximity Read ↗

Computational modeling of protracted HCMV replication using genome substrates and protein temporal profilesSemantic proximity Read ↗

Dynamic metabolic modeling of ATP allocation during viral infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.