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Article

A whole-cell computational model predicts phenotype from genotype.

Cell - 20 Jul 2012

Karr Jonathan R, Sanghvi Jayodita C, Macklin Derek N, Gutschow Miriam V, Jacobs Jared M, Bolival Benjamin, Assad-Garcia Nacyra, Glass John I, Covert Markus W

Abstract excerpt

Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. We report a whole-cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes...

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Identifiers

PMID: 22817898
DOI: 10.1016/j.cell.2012.05.044
PMCID: PMC3413483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22817898-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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