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Article

Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model.

BMC systems biology - 28 Jun 2013

Oguz Cihan, Laomettachit Teeraphan, Chen Katherine C, Watson Layne T, Baumann William T, Tyson John J

Abstract excerpt

BACKGROUND: Parameter estimation from experimental data is critical for mathematical modeling of protein regulatory networks. For realistic networks with dozens of species and reactions, parameter estimation is an especially challenging task. In this study, we present an approach for parameter estimation that is effective in fitting a model of the budding yeast cell cycle (comprising 26 nonlinear ordinary...

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Identifiers

PMID: 23809412
DOI: 10.1186/1752-0509-7-53
PMCID: PMC3702416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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