Article
Comprehensive understanding of Saccharomyces cerevisiae phenotypes with whole-cell model WM_S288C.
Biotechnology and bioengineering - 1 May 2020
Ye Chao, Xu Nan, Gao Cong, Liu Gaoqiang, Xu Jianzhong, Zhang Weiguo, Chen Xiulai, Nielsen Jens, Liu Liming
Abstract excerpt
Biological network construction for Saccharomyces cerevisiae is a widely used approach for simulating phenotypes and designing cell factories. However, due to a complicated regulatory mechanism governing the translation of genotype to phenotype, precise prediction of phenotypes remains challenging. Here, we present WM_S288C, a computational whole-cell model that includes 15 cellular states and 26 cellular...
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