Accelerated discovery via a whole-cell model.

Abstract excerpt

To test the promise of whole-cell modeling to facilitate scientific inquiry, we compared growth rates simulated in a whole-cell model with experimental measurements for all viable single-gene disruption Mycoplasma genitalium strains. Discrepancies between simulations and experiments led to predictions about kinetic parameters of specific enzymes that we subsequently validated. These findings represent, to our...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Catalysis
• Share to Computer Simulation
• Share to Gene Expression Regulation, Bacterial