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Article

Construction of Multiscale Genome-Scale Metabolic Models: Frameworks and Challenges.

Biomolecules - 19 May 2022

Bi Xinyu, Liu Yanfeng, Li Jianghua, Du Guocheng, Lv Xueqin, Liu Long

Abstract excerpt

Genome-scale metabolic models (GEMs) are effective tools for metabolic engineering and have been widely used to guide cell metabolic regulation. However, the single gene-protein-reaction data type in GEMs limits the understanding of biological complexity. As a result, multiscale models that add constraints or integrate omics data based on GEMs have been developed to more accurately predict phenotype from...

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PMID: 35625648
DOI: 10.3390/biom12050721
PMCID: PMC9139095

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