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Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma

28 Sept 2010

Abstract excerpt

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that plays a key role in hepatocyte differentiation and the maintenance of hepatic function, but its role in hepatocarcinogenesis has yet to be examined. Here, we report evidence of a suppressor role for HNF4α in liver cancer. HNF4α expression was progressively decreased in the diethylinitrosamine-induced rat model of liver carcinogenesis. In human...

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PMID: 20876809
DOI: 10.1158/0008-5472.can-10-0824

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