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Article

The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.

Stem cell research & therapy - 4 Nov 2019

Wang Xue, Hassan Waseem, Zhao Jing, Bakht Sahar, Nie Yunjuan, Wang Ying, Pang Qingfeng, Huang Zhaohui

Abstract excerpt

Hepatocyte nuclear factor-1 alpha (HNF-1α) is a transcription factor expressed predominantly in the liver among other organs. Structurally, it contains POU-homeodomain that binds to DNA and form proteins that help in maintaining cellular homeostasis, controlling metabolism, and differentiating cell lineages. Scientific research over the period of three decades has reported it as an important player in various...

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Identifiers

PMID: 31685031
DOI: 10.1186/s13287-019-1438-z
PMCID: PMC6829964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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