Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of Highly Functional Hepatocytes from Human Umbilical Cord Mesenchymal Stem Cells by HNF4α Transduction

19 Aug 2014

Abstract excerpt

AIM: To investigate the differentiation potential of human umbilical mesenchymal stem cells (HuMSCs) and the key factors that facilitate hepatic differentiation. METHODS: HuMSCs were induced to become hepatocyte-like cells according to a previously published protocol. The differentiation status of the hepatocyte-like cells was examined by observing the morphological changes under an inverted microscope and by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to Mesenchymal stem cell research
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25137413
DOI: 10.1371/journal.pone.0104133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of Highly Functional Hepatocytes from Human Umbilical Cord Mesenchymal Stem Cells by HNF4α TransductionPMID 25137413Read ↗

HNF-4α determines hepatic differentiation of human mesenchymal stem cells from bone marrowSemantic proximity Read ↗

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α TransductionSemantic proximity Read ↗

Overexpression of HNF4α enhances umbilical cord mesenchymal stem cell function to treat acute liver failure in mice through macrophage polarizationSemantic proximity Read ↗

Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α geneSemantic proximity Read ↗

Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cellsSemantic proximity Read ↗

Hepatocyte nuclear factor 4α induces a tendency of differentiation and activation of rat hepatic stellate cells.Semantic proximity Read ↗

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatmentSemantic proximity Read ↗

The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.Semantic proximity Read ↗

HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines.Semantic proximity Read ↗

Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver FailureSemantic proximity Read ↗

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cellsSemantic proximity Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.