Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis

28 Sept 2022

Abstract excerpt

Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been...

Topics

Join the communities discussing this publication.

Metabolism, Diabetes, and Cancer
Pancreatic and Hepatic Oncology Research
Pancreatic function and diabetes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36249028
DOI: 10.3389/fonc.2022.1011230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesisPMID 36249028Read ↗

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseasesSemantic proximity Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatmentSemantic proximity Read ↗

Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic DisordersSemantic proximity Read ↗

Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestineSemantic proximity Read ↗

The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.Semantic proximity Read ↗

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networksSemantic proximity Read ↗

Role of HNF6 in liver homeostasis and pathophysiologySemantic proximity Read ↗

Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α.Semantic proximity Read ↗

HNF4α isoforms: the fraternal twin master regulators of liver functionSemantic proximity Read ↗

Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescenceSemantic proximity Read ↗

Progressive loss of hepatocyte nuclear factor 4 alpha activity in chronic liver diseases in humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.