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Article

Role of HNF6 in liver homeostasis and pathophysiology

5 Feb 2025

Abstract excerpt

BACKGROUND: Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly expressed as an HNF in the liver. MAIN BODY: HNF6 regulates not only the formation of the liver but also the proliferation and...

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PMID: 39910442
DOI: 10.1186/s10020-025-01105-9

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