Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene

9 Jul 2008

Abstract excerpt

UNLABELLED: Previous studies have shown that hepatocyte nuclear factor-4alpha (HNF4alpha) is a central regulator of differentiated hepatocyte phenotype and forced expression of HNF4alpha could promote reversion of tumors toward a less invasive phenotype. However, the effect of HNF4alpha on cancer stem cells (CSCs) and the treatment of hepatocellular carcinoma (HCC) with HNF4alpha have not been reported. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Liver physiology and pathology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18925631
DOI: 10.1002/hep.22510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α genePMID 18925631Read ↗

Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in miceSemantic proximity Read ↗

Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular CarcinomaSemantic proximity Read ↗

Induction of Highly Functional Hepatocytes from Human Umbilical Cord Mesenchymal Stem Cells by HNF4α TransductionSemantic proximity Read ↗

HNF-4α determines hepatic differentiation of human mesenchymal stem cells from bone marrowSemantic proximity Read ↗

The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.Semantic proximity Read ↗

Hepatocyte nuclear factor 4α induces a tendency of differentiation and activation of rat hepatic stellate cells.Semantic proximity Read ↗

Overexpression of HNF4α enhances umbilical cord mesenchymal stem cell function to treat acute liver failure in mice through macrophage polarizationSemantic proximity Read ↗

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatmentSemantic proximity Read ↗

Silencing HSF4 can inhibit the proliferation of HCC cellsSemantic proximity Read ↗

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α TransductionSemantic proximity Read ↗

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesisSemantic proximity Read ↗

Adenovirus-mediated hepatocyte nuclear factor-4alpha overexpression maintains liver phenotype in cultured rat hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.