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Article

CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas.

Annals of neurology - 1 Sept 2015

Gleize Vincent, Alentorn Agusti, Connen de Kérillis Léa, Labussière Marianne, Nadaradjane Aravidan A, Mundwiller Emeline, Ottolenghi Chris, Mangesius Stephanie, Rahimian Amithys, Ducray François, Mokhtari Karima, Villa Chiara, Sanson Marc

Abstract excerpt

OBJECTIVE: CIC gene is frequently mutated in oligodendroglial tumors with 1p19q codeletion. However, clinical and biological impact remain poorly understood. METHODS: We sequenced the CIC gene on 127 oligodendroglial tumors (109 with the 1p19q codeletion) and analyzed patients' outcome. We compared magnetic resonance imaging, transcriptomic profile, and CIC protein expression of CIC wild-type (WT) and mutant...

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Source

Identifiers

PMID: 26017892
DOI: 10.1002/ana.24443

Genes

CIC
CCND1
IDH1
DUSP4
ETV1
ETV4
ETV5
SPRED1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CIC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas.PMID 26017892Read ↗

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.Semantic proximity Read ↗

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ETV/Pea3 family transcription factor-encoding genes are overexpressed in CIC-mutant oligodendrogliomas.Semantic proximity Read ↗

Loss of CIC and FUBP1 expressions are potential markers of shorter time to recurrence in oligodendroglial tumors.Semantic proximity Read ↗

Tumor-specific mutations in low-frequency genes affect their functional properties.Semantic proximity Read ↗

Integrative multi-omic analysis reveals neurodevelopmental gene dysregulation in CIC-knockout and IDH1-mutant cells.Semantic proximity Read ↗

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Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomasSemantic proximity Read ↗

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