TCF12 is mutated in anaplastic oligodendroglioma.

doi:10.1038/ncomms8207

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Article

TCF12 is mutated in anaplastic oligodendroglioma.

Nature communications - 12 Jun 2015

Labreche Karim, Simeonova Iva, Kamoun Aurélie, Gleize Vincent, Chubb Daniel, Letouzé Eric, Riazalhosseini Yasser, Dobbins Sara E, Elarouci Nabila, Ducray Francois, de Reyniès Aurélien, Zelenika Diana, Wardell Christopher P, Frampton Mathew, Saulnier Olivier, Pastinen Tomi, Hallout Sabrina, Figarella-Branger Dominique, Dehais Caroline, Idbaih Ahmed, Mokhtari Karima, Delattre Jean-Yves, Huillard Emmanuelle, Mark Lathrop G, Sanson Marc, Houlston Richard S

Abstract excerpt

Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome sequencing, identifying previously reported frequent somatic mutations in CIC and FUBP1. We also identified recurrent mutations in...

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Identifiers

PMID: 26068201
DOI: 10.1038/ncomms8207
PMCID: PMC4490400

Genes

TCF12
CIC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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