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Article

Tumor-specific mutations in low-frequency genes affect their functional properties.

Journal of neuro-oncology - 1 May 2015

Erdem-Eraslan Lale, Heijsman Daphne, de Wit Maurice, Kremer Andreas, Sacchetti Andrea, van der Spek Peter J, Sillevis Smitt Peter A E, French Pim J

Abstract excerpt

Causal genetic changes in oligodendrogliomas (OD) with 1p/19q co-deletion include mutations in IDH1, IDH2, CIC, FUBP1, TERT promoter and NOTCH1. However, it is generally assumed that more somatic mutations are required for tumorigenesis. This study aimed to establish whether genes mutated at low frequency can be involved in OD initiation and/or progression. We performed whole-genome sequencing on three anaplastic...

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Identifiers

PMID: 25694352
DOI: 10.1007/s11060-015-1741-1
PMCID: PMC4436689

Genes

CIC
GDI1
IDH1
IDH2
MAGEH1
NOTCH1
NTN4
SASH3
TERT
XPO7

Provenance

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