Article
Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
Science (New York, N.Y.) - 9 Sept 2011
Bettegowda Chetan, Agrawal Nishant, Jiao Yuchen, Sausen Mark, Wood Laura D, Hruban Ralph H, Rodriguez Fausto J, Cahill Daniel P, McLendon Roger, Riggins Gregory, Velculescu Victor E, Oba-Shinjo Sueli Mieko, Marie Suely Kazue Nagahashi, Vogelstein Bert, Bigner Darell, Yan Hai, Papadopoulos Nickolas, Kinzler Kenneth W
Abstract excerpt
Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene...
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