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Article

Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A.

BMC infectious diseases - 28 Jun 2009

Murray Ruth, Boyd Dave, Levett Paul N, Mulvey Michael R, Alfa Michelle J

Abstract excerpt

BACKGROUND: The increased severity of disease associated with the NAP1 strain of Clostridium difficile has been attributed to mutations to the tcdC gene which codes for a negative regulator of toxin production. To assess the role of hyper-production of Toxins A and B in clinical isolates of Clostridium difficile, two NAP1-related and five NAP1 non-related strains were compared. METHODS: Sequencing was performed...

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Identifiers

PMID: 19558711
DOI: 10.1186/1471-2334-9-103
PMCID: PMC2707377

Genes

CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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