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Article

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons.

Human molecular genetics - 1 Jun 2014

Williams Emily Cunningham, Zhong Xiaofen, Mohamed Ahmed, Li Ronghui, Liu Yan, Dong Qiping, Ananiev Gene E, Mok Jonathan Chern Choong, Lin Benjamin Ray, Lu Jianfeng, Chiao Cassandra, Cherney Rachel, Li Hongda, Zhang Su-Chun, Chang Qiang

Abstract excerpt

The disease mechanism of Rett syndrome (RTT) is not well understood. Studies in RTT mouse models have suggested a non-cell-autonomous role for astrocytes in RTT pathogenesis. However, it is not clear whether this is also true for human RTT astrocytes. To establish an in vitro human RTT model, we previously generated isogenic induced pluripotent stem cell (iPSC) lines from several RTT patients carrying different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24419315
DOI: 10.1093/hmg/ddu008
PMCID: PMC4014193

Genes

GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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