Article

Human TSC2 Mutant Cells Exhibit Aberrations in Early Neurodevelopment Accompanied by Changes in the DNA Methylome

2024-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Tuberous Sclerosis Complex (TSC) is a debilitating developmental disorder characterized by a variety of clinical manifestations. While benign tumors in the heart, lungs, kidney, and brain are all hallmarks of the disease, the most severe symptoms of TSC are often neurological, including seizures, autism, psychiatric disorders, and intellectual disabilities. TSC is caused by loss of function muta...

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Literature Corpus work: 2c123fe8-d347-5e13-95cc-34f671a552ca
DOI: 10.1101/2024.06.04.597443

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