Article
Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Nov 2013
Nguyen Minh Vu Chuong, Felice Christy A, Du Fang, Covey Matthew V, Robinson John K, Mandel Gail, Ballas Nurit
Abstract excerpt
Mutations in the methyl-CpG binding protein 2 gene, Mecp2, affect primarily the brain and lead to a wide range of neuropsychiatric disorders, most commonly Rett syndrome (RTT). Although the neuropathology of RTT is well understood, the cellular and molecular mechanism(s), which lead to the disease initiation and progression, has yet to be elucidated. RTT was initially attributed only to neuronal dysfunction, but...
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