Article

Generation of functional iPSC-derived astrocytes to model the neurodevelopmental disorder, Rett Syndrome

2021-01-01

Abstract excerpt

Rett Syndrome (RTT) is one of the leading causes of mental disability in girls. It is a neurodevelopmental disorder caused by mutations in the MeCP2 gene, a ubiquitously expressed transcriptional repressor whose expression is particularly enriched in the central nervous system (CNS). It affects around 1 in 10,000-15,000 girls. It currently has no cure and treatments focus on symptom management; therefore, it is im...

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Literature Corpus work: 59a1ad5e-2e19-5c0f-964b-3c3dbaeecfe9
DOI: 10.48780/publications.aston.ac.uk.00043265

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