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Article

Lithium-induced Clock Gene Expression in Lymphoblastoid Cells of Bipolar Affective Patients

26 May 2015

Abstract excerpt

INTRODUCTION: Disturbances of circadian rhythms occur in all episodes of bipolar disorder (BD). Lithium, as gold-standard in the maintenance treatment of BD, is known to influence circadian processes. METHODS: In a pilot study lymphoblastoid cell lines (LCLs) were generated from 8 BD patients and 6 healthy controls. The LCLs were treated with lithiumchloride (LiCl) for 3 weeks. Cell cycles were then synchronized...

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PMID: 26011568
DOI: 10.1055/s-0035-1549946

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