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Article

Lithium-induced gene expression alterations in two peripheral cell models of bipolar disorder

25 Oct 2017

Abstract excerpt

Objectives: The aim of our study was to investigate molecular mechanisms of lithium action by studying the gene expression profile of peripheral cell models generated from bipolar patients (BD) and healthy controls (HC).Methods: EBV-immortalised lymphoblastoid cells (LCLs) and fibroblast cells from BD and HC were incubated with either lithium chloride or plain medium for 3 weeks. We first conducted a microarray...

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PMID: 29067888
DOI: 10.1080/15622975.2017.1396357

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