Article
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer science - 1 Aug 2015
Hakiri Shuhei, Osada Hirotaka, Ishiguro Futoshi, Murakami Hideki, Murakami-Tonami Yuko, Yokoi Kohei, Sekido Yoshitaka
Abstract excerpt
Malignant mesothelioma (MM) shows inactivation of the BRCA1-associated protein 1 (BAP1) gene. In this study, we found BAP1 mutations in 5 (26%) of the 19 cell lines that we established from Japanese MM patients, and examined functional differences between the WT and mutant BAP1. First, we studied the subcellular localization of BAP1, demonstrating that the WT primarily resides in the nucleus and that the mutant...
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