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BAP1, a tumor suppressor gene driving malignant mesothelioma

1 Jun 2017

Abstract excerpt

Like cancer generally, malignant mesothelioma (MM) is a genetic disease at the cellular level. DNA copy number analysis of mesothelioma specimens has revealed a number of recurrent sites of chromosomal loss, including 3p21.1, 9p21.3, and 22q12.2. The key inactivated driver genes located at 9p21.1 and 22q12.2 were discovered two decades ago as being the tumor suppressor loci CDKN2A and NF2 , respectively. Only...

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PMID: 28713672
DOI: 10.21037/tlcr.2017.05.03

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