Article
Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma.
Cancer science - 1 May 2012
Yoshikawa Yoshie, Sato Ayuko, Tsujimura Tohru, Emi Mitsuru, Morinaga Tomonori, Fukuoka Kazuya, Yamada Shusai, Murakami Aki, Kondo Nobuyuki, Matsumoto Seiji, Okumura Yoshitomo, Tanaka Fumihiro, Hasegawa Seiki, Nakano Takashi, Hashimoto-Tamaoki Tomoko
Abstract excerpt
In the present study, we analyzed genomic alterations of BRCA1-associated protein 1 (BAP1) in 23 malignant mesotheliomas (MMs), 16 epithelioid and seven non-epithelioid, consisting of 18 clinical specimens and five established cell lines. In examining these samples for homozygous deletions and sequence-level mutations, we found biallelic BAP1 gene alterations in 14 of 23 MMs (61%). Seven of these 14 MMs had...
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