Article

Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy

2018-07-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Loss of function of BRCA1 associated protein 1 (BAP1) is observed in about 50% of malignant pleural mesothelioma (MPM) cases. The aim of this study was to investigate whether this aspect could be exploited for targeted therapy. <h4>Methods</h4> A genetically engineered model was established expressing either functional or nonfunctional BAP1 and whole-genome siRNA screens...

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Literature Corpus work: 873fd83d-6466-5dcc-a485-763c51f8fc2a
DOI: 10.1101/381533

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