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Article

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.

Journal of dental research - 1 Dec 2018

Gou Y, Li J, Jackson-Weaver O, Wu J, Zhang T, Gupta R, Cho I, Ho T V, Chen Y, Li M, Richard S, Wang J, Chai Y, Xu J

Abstract excerpt

Cleft palate is among the most common birth defects. Currently, only 30% of cases have identified genetic causes, whereas the etiology of the majority remains to be discovered. We identified a new regulator of palate development, protein arginine methyltransferase 1 (PRMT1), and demonstrated that disruption of PRMT1 function in neural crest cells caused complete cleft palate and craniofacial malformations. PRMT1...

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Source

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Identifiers

PMID: 29986157
DOI: 10.1177/0022034518785164
PMCID: PMC6728548

Genes

PRMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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