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Article

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.

Genome research - 1 Feb 2012

Hon Gary C, Hawkins R David, Caballero Otavia L, Lo Christine, Lister Ryan, Pelizzola Mattia, Valsesia Armand, Ye Zhen, Kuan Samantha, Edsall Lee E, Camargo Anamaria Aranha, Stevenson Brian J, Ecker Joseph R, Bafna Vineet, Strausberg Robert L, Simpson Andrew J, Ren Bing

Abstract excerpt

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors, as well as changes in chromatin modifications as caused by genetic mutations of the chromatin-modifying machinery. However, the extent of epigenetic alterations in cancer cells has not been fully characterized. Here, we describe...

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Share to Chromatin
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Methylation

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Share to Repetitive Sequences, Nucleic Acid

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Identifiers

PMID: 22156296
DOI: 10.1101/gr.125872.111
PMCID: PMC3266032

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