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Article

Attenuation of hearing loss in DBA/2J mice by anti-apoptotic treatment.

Hearing research - 1 Sept 2015

Yang Linlin, Zhang Heng, Han Xu, Zhao Xin, Hu Fangyuan, Li Ping, Xie Gang, Gao Lixiang, Cheng Lin, Song Xicheng, Han Fengchan

Abstract excerpt

DBA/2J mice are characterized by early onset hearing loss at about 3-4 weeks of age. Mutations in cadherin 23 (Cdh23) and fascin-2 (Fscn2) are responsible for the phenotypes, but the underlying mechanism is unknown. In the present study, DBA/2J mice displayed progressive hair cell loss and degeneration of spiral ganglion neurons (SGNs) after 2 weeks of age; however, the mRNA level of Caspase-3 in the inner ears...

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Identifiers

PMID: 26003529
DOI: 10.1016/j.heares.2015.05.006

Genes

ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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