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Article

Dominant negative connexin26 mutation R75W causing severe hearing loss influences normal programmed cell death in postnatal organ of Corti.

BMC genetics - 3 Jan 2014

Inoshita Ayako, Karasawa Keiko, Funakubo Megumi, Miwa Asuka, Ikeda Katsuhisa, Kamiya Kazusaku

Abstract excerpt

BACKGROUND: The greater epithelial ridge (GER) is a developmental structure in the maturation of the organ of Corti. Situated near the inner hair cells of neonatal mice, the GER undergoes a wave of apoptosis after postnatal day 8 (P8). We evaluated the GER from P8 to P12 in transgenic mice that carry the R75W + mutation, a dominant-negative mutation of human gap junction protein, beta 2, 26 kDa (GJB2) (also known...

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Source

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Identifiers

PMID: 24387126
DOI: 10.1186/1471-2156-15-1
PMCID: PMC3893426

Genes

GJB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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