Article
Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice.
G3 (Bethesda, Md.) - 3 Oct 2018
Liu Xiang, Zhao Mengmeng, Xie Yi, Li Ping, Wang Oumei, Zhou Bingxin, Yang Linlin, Nie Yao, Cheng Lin, Song Xicheng, Jin Changzhu, Han Fengchan
Abstract excerpt
Fascin2 (FSCN2) is an actin cross-linking protein that is mainly localized in retinas and in the stereocilia of hair cells. Earlier studies showed that a deletion mutation in human FASCIN2 (FSCN2) gene could cause autosomal dominant retinitis pigmentosa. Recent studies have indicated that a missense mutation in mouse Fscn2 gene (R109H) can contribute to the early onset of hearing loss in DBA/2J mice. To explore...
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