Article
Caspase-mediated apoptosis in the cochleae contributes to the early onset of hearing loss in A/J mice.
ASN neuro - 1 Jan 2000
Han Xu, Ge Ruli, Xie Gang, Li Ping, Zhao Xin, Gao Lixiang, Zhang Heng, Wang Omei, Huang Fei, Han Fengchan
Abstract excerpt
A/J and C57BL/6 J (B6) mice share a mutation in Cdh23 (ahl allele) and are characterized by age-related hearing loss. However, hearing loss occurs much earlier in A/J mice at about four weeks of age. Recent study has revealed that a mutation in citrate synthase (Cs) is one of the main contributors, but the mechanism is largely unknown. In the present study, we showed that A/J mice displayed more severe...
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