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Article

Anti-apoptotic gene Bcl2 is required for stapes development and hearing.

Cell death & disease - 9 Aug 2012

Carpinelli M R, Wise A K, Arhatari B D, Bouillet P, Manji S S M, Manning M G, Cooray A A, Burt R A

Abstract excerpt

In this paper we describe novel and specific roles for the apoptotic regulators Bcl2 and Bim in hearing and stapes development. Bcl2 is anti-apoptotic while Bim is pro-apoptotic. Characterization of the auditory systems of mice deficient for these molecules revealed that Bcl2⁻/⁻ mice suffered severe hearing loss. This was conductive in nature and did not affect sensory cells of the inner ear, with cochlear hair...

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Source

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Identifiers

PMID: 22874999
DOI: 10.1038/cddis.2012.100
PMCID: PMC3434664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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