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Article

Inner ear dysfunction in caspase-3 deficient mice.

BMC neuroscience - 12 Oct 2011

Makishima Tomoko, Hochman Lara, Armstrong Patrick, Rosenberger Eric, Ridley Ryan, Woo Minna, Perachio Adrian, Wood Scott

Abstract excerpt

BACKGROUND: Caspase-3 is one of the most downstream enzymes activated in the apoptotic pathway. In caspase-3 deficient mice, loss of cochlear hair cells and spiral ganglion cells coincide closely with hearing loss. In contrast with the auditory system, details of the vestibular phenotype have not been characterized. Here we report the vestibular phenotype and inner ear anatomy in the caspase-3 deficient...

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Identifiers

PMID: 21988729
DOI: 10.1186/1471-2202-12-102
PMCID: PMC3208590

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ABR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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