Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.

Scientific reports - 18 Jan 2016

Honkura Yohei, Matsuo Hirotaka, Murakami Shohei, Sakiyama Masayuki, Mizutari Kunio, Shiotani Akihiro, Yamamoto Masayuki, Morita Ichiro, Shinomiya Nariyoshi, Kawase Tetsuaki, Katori Yukio, Motohashi Hozumi

Abstract excerpt

Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing deficits. Recent studies have demonstrated that the pathogenesis of NIHL is closely related to ischemia-reperfusion injury of cochlea, which is caused by blood flow decrease and free radical production due to excessive noise. This suggests that protecting the cochlea from oxidative stress is an effective therapeutic approach for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cochlea
Share to Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss, Noise-Induced

Share to Imidazoles

Share to Lipid Peroxidation

Share to NF-E2-Related Factor 2

Share to Protective Agents

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 26776972
DOI: 10.1038/srep19329
PMCID: PMC4726010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.PMID 26776972Read ↗

ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune ResponseSemantic proximity Read ↗

Integration of transcriptomics and proteomics uncovers novel targets underlying the protective effects of Nrf2 knockout in HEI-OC1 cellsSemantic proximity Read ↗

Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction.Semantic proximity Read ↗

Polymorphisms in the FAS gene are associated with susceptibility to noise-induced hearing loss.Semantic proximity Read ↗

<i>In silico</i> transcriptomics identifies FDA-approved drugs and biological pathways for protection against cisplatin-induced hearing lossSemantic proximity Read ↗

Gene Expression Changes for Antioxidants Pathways in the Mouse Cochlea: Relations to Age-related Hearing DeficitsSemantic proximity Read ↗

Mechanism and Protection of Radiotherapy Induced Sensorineural Hearing Loss for Head and Neck CancerSemantic proximity Read ↗

Effects of acute exposure to Al2O3-NPs (α and γ) and white noise and their combination on Cochlea structure and function in Wistar RatSemantic proximity Read ↗

Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress.Semantic proximity Read ↗

[Effects of SOD2 and its C47T mutation on oxidative injury in cochlea hair cell].Semantic proximity Read ↗

Mechanisms of cisplatin ototoxicity and progress in otoprotection.Semantic proximity Read ↗

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.