Article
Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease.
Gastroenterology - 1 Sept 2015
Setty Mala, Discepolo Valentina, Abadie Valérie, Kamhawi Sarah, Mayassi Toufic, Kent Andrew, Ciszewski Cezary, Maglio Maria, Kistner Emily, Bhagat Govind, Semrad Carol, Kupfer Sonia S, Green Peter H, Guandalini Stefano, Troncone Riccardo, Murray Joseph A, Turner Jerrold R, Jabri Bana
Abstract excerpt
BACKGROUND & AIMS: The mechanisms of tissue destruction during progression of celiac disease are poorly defined. It is not clear how tissue stress and adaptive immunity contribute to the activation of intraepithelial cytotoxic T cells and the development of villous atrophy. We analyzed epithelial cells and intraepithelial cytotoxic T cells in family members of patients with celiac disease, who were without any...
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