Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease

2 Jun 2021

Abstract excerpt

Several environmental, genetic, and immune factors create a “perfect storm” for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase 2 (TG2) generating peptides that bind strongly to the predisposing HLA-DQ2 or HLA-DQ8 molecules, and the ensuing unrestrained T cell response. T cell immunity is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Celiac Disease Research and Management
Share to Eosinophilic Esophagitis
Share to Microscopic Colitis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34149709
DOI: 10.3389/fimmu.2021.674313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac DiseasePMID 34149709Read ↗

Gene-Environment Interactions in Celiac Disease: The Role of the Intestinal Epithelium.Semantic proximity Read ↗

New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease.Semantic proximity Read ↗

Celiac disease: an immunological jigsaw.Semantic proximity Read ↗

Immunopathogenesis and environmental triggers in coeliac diseaseSemantic proximity Read ↗

An updated overview on celiac disease: from immuno-pathogenesis and immuno-genetics to therapeutic implications.Semantic proximity Read ↗

Celiac disease: sandwiched between innate and adaptive immune responses induced by gluten.Semantic proximity Read ↗

The adaptive immune response in celiac disease.Semantic proximity Read ↗

Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac diseaseSemantic proximity Read ↗

Pathophysiology and immunogenetics of celiac disease.Semantic proximity Read ↗

The pathogenesis of coeliac disease.Semantic proximity Read ↗

Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature.Semantic proximity Read ↗

“Coelionomics”: towards understanding the molecular pathology of coeliac diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.