Article

Cellular Stress and Immune Activation in Celiac Disease: Is the Chaperone System a Key Player?

2026-03-25

Abstract excerpt

Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by the ingestion of gluten in genetically predisposed individuals. While the adaptive immune response to deamidated gliadin peptides represents a central pathogenic mechanism, growing ev-idence suggests that epithelial stress and innate immune activation play a fundamental role in the onset and persistence of the disease. Heat shock proteins (H...

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Literature Corpus work: 18531698-a6c4-55a0-90ab-273bf01665df
DOI: 10.20944/preprints202603.1957.v1

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