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Article

Effect of viral DNA methylation on expression of hepatitis B virus proteins depends on the virus genotype.

Virus genes - 1 Aug 2020

Nakamura Takuya, Inoue Jun, Ninomiya Masashi, Kakazu Eiji, Iwata Tomoaki, Takai Satoshi, Sano Akitoshi, Kogure Takayuki, Shimosegawa Tooru, Masamune Atsushi

Abstract excerpt

The frequency of HBV genomic methylation in the liver was reported to vary among patients, but the detailed mechanism is still unknown. In this study, the effects of HBV genome methylation on HBV replication were investigated in vitro. A total of 6 plasmids containing 1.24-fold the HBV genome of different genotypes (subgenotypes A1, A2, B1, and C2) were purified after in vitro methylation with CpG...

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Share to DNA Methylation
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hep G2 Cells

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

Share to Hepatitis B virus

Share to Virus Replication

Source

Identifiers

PMID: 32361814
DOI: 10.1007/s11262-020-01761-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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