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Article

Hepatitis B viral DNA is methylated in liver tissues

7 Aug 2007

Abstract excerpt

The mechanisms that regulate hepatitis B virus (HBV) replication within the liver are poorly understood. Given that methylation of CpG islands regulates gene expression in human tissues, we sought to identify CpG islands in HBV-DNA and to determine if they are methylated in human tissues. In silico analysis demonstrated three CpG islands in HBV genotype A sequences, two of which were of particular interest...

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PMID: 18184192
DOI: 10.1111/j.1365-2893.2007.00905.x

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