Article
Epigenetic landscape influences the liver cancer genome architecture.
Nature communications - 24 Apr 2018
Hama Natsuko, Totoki Yasushi, Miura Fumihito, Tatsuno Kenji, Saito-Adachi Mihoko, Nakamura Hiromi, Arai Yasuhito, Hosoda Fumie, Urushidate Tomoko, Ohashi Shoko, Mukai Wakako, Hiraoka Nobuyoshi, Aburatani Hiroyuki, Ito Takashi, Shibata Tatsuhiro
Abstract excerpt
The accumulations of different types of genetic alterations such as nucleotide substitutions, structural rearrangements and viral genome integrations and epigenetic alterations contribute to carcinogenesis. Here, we report correlation between the occurrence of epigenetic features and genetic aberrations by whole-genome bisulfite, whole-genome shotgun, long-read, and virus capture sequencing of 373 liver cancers....
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