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Article

DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences.

Genome research - 1 Mar 2015

Watanabe Yoshiyuki, Yamamoto Hiroyuki, Oikawa Ritsuko, Toyota Minoru, Yamamoto Masakazu, Kokudo Norihiro, Tanaka Shinji, Arii Shigeki, Yotsuyanagi Hiroshi, Koike Kazuhiko, Itoh Fumio

Abstract excerpt

Integration of DNA viruses into the human genome plays an important role in various types of tumors, including hepatitis B virus (HBV)-related hepatocellular carcinoma. However, the molecular details and clinical impact of HBV integration on either human or HBV epigenomes are unknown. Here, we show that methylation of the integrated HBV DNA is related to the methylation status of the flanking human genome. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25653310
DOI: 10.1101/gr.175240.114
PMCID: PMC4352876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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