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Article

Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA

11 Feb 2010

Abstract excerpt

Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from chronic hepatitis B virus (HBV) infection. Recently, methylation has been identified as a novel host defense mechanism, and methylation of viral DNA leads to downregulation of HBV gene expression. To better understand the mechanisms of HBV methylation, cell lines were exposed to HBV using a model system that mimics...

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Identifiers

PMID: 20147412
DOI: 10.1128/jvi.02280-09

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