Article
Frequency of TERT Promoter Mutations in Prostate Cancer.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2015
Stoehr Robert, Taubert Helge, Zinnall Ulrike, Giedl Johannes, Gaisa Nadine T, Burger Maximilian, Ruemmele Petra, Hurst Carolyn D, Knowles Margaret A, Wullich Bernd, Hartmann Arndt
Abstract excerpt
OBJECTIVE: Recently, recurrent mutations within the core promoter of the human telomerase reverse transcriptase (TERT) gene generating consensus binding sites for ETS transcription factor family members were described in melanomas and other malignancies (e.g. bladder cancer, hepatocellular carcinoma). These mutations were discussed as early drivers for malignant transformation. In prostate cancer (PrCa) TERT...
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