Article
High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma.
Virchows Archiv : an international journal of pathology - 1 Oct 2016
Nguyen Doreen, Taheri Diana, Springer Simeon, Cowan Morgan, Guner Gunes, Mendoza Rodriguez Maria Angelica, Wang Yuxuan, Kinde Isaac, VandenBussche Christopher J, Olson Matthew T, Ricardo Bernardo F P, Cunha Isabela, Fujita Kazutoshi, Ertoy Dilek, Kinzler Kenneth W, Bivalacqua Trinity J, Papadopoulos Nickolas, Vogelstein Bert, Netto George J
Abstract excerpt
Somatic activating mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the most common genetic alterations in urothelial carcinoma (UC) of the bladder and upper urinary tract. Little is known, however, about TERT-mutation status in the relatively uncommon but clinically aggressive micropapillary (MPC) variant. We evaluated the presence of TERT promoter mutations in MPC of the bladder...
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